XKR3

Across TCGA cell cohorts, XKR3 mutation is significantly associated with the RNA expression of many other genes, with 479 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XKR3-associated genes across cancer lineages are MCAT, ST13, and POLR3H. Each is linked with XKR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR3-to-partner and partner-to-XKR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCAT grouped by XKR3-low versus XKR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR3→partner) and Y-score (partner→XKR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCAT →	+0.707	+3.082	<.001	.007	3	1
LARGE_INTESTINE	ST13 →	+0.518	+3.364	.004	.002	3	1
LARGE_INTESTINE	POLR3H →	+0.916	+3.364	<.001	.002	3	1
LARGE_INTESTINE	AHSA1 →	+0.501	+3.234	<.001	.004	3	1
LARGE_INTESTINE	ZC3H14 →	+0.657	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PIM2 →	+0.512	+3.064	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 479 associations by consensus.

MCAT by XKR3 expression — LARGE_INTESTINE

Explore this box plot interactively →