XIST

Across TCGA pan-cancer cohorts, XIST Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated XIST data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XIST Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated XIST expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, OV, and THYM are the cancer types where XIST Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.945	0.426	.004	24	view →
OV	DFS	Median	II,III,IV	0.302	0.543	.033	18	view →
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
SARC	DFS	Median	All	0.159	0.594	.019	6	view →
HNSC	OS	Median	III,IV	0.230	0.560	.029	3	view →
LUSC	OS	Median	II,III,IV	1.000	0.627	.048	1	view →
SKCM	OS	Median	II,III,IV	0.815	0.713	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

XIST–UCEC (DFS)

Open the UCEC breakdown →