XIRP2

Across TCGA patient cohorts, XIRP2 mutation is significantly associated with the RNA expression of many other genes, with 11,417 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible XIRP2-associated genes across cancer lineages are TIMM44, FOXM1, and KIF20A. Each is linked with XIRP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both XIRP2-to-partner and partner-to-XIRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by XIRP2-low versus XIRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP2→partner) and Y-score (partner→XIRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.262	+1.214	<.001	<.001	3	7
LUAD	FOXM1 →	+0.590	+1.060	<.001	<.001	3	7
LUAD	KIF20A →	+0.496	+0.916	<.001	<.001	3	7
LUAD	LMNB1 →	+0.367	+1.097	<.001	.001	3	7
SKCM	PSMC3IP →	+0.417	+1.057	<.001	<.001	3	7
STAD	EMCN →	-0.469	-2.807	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,417 associations by consensus.

TIMM44 by XIRP2 expression — UCEC

Explore this box plot interactively →