XIRP2-AS1

Across TCGA pan-cancer cohorts, XIRP2-AS1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated XIRP2-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher XIRP2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated XIRP2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and ESCA show a favorable association.

HNSC, KIRC, and THYM are the cancer types where XIRP2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.285	0.679	.004	102	view →
KIRC	DFS	Tertile	IV	0.229	0.638	<.001	72	view →
THYM	DFS	Tertile	All	0.123	0.871	<.001	36	view →
LGG	OS	Tertile	All	0.801	0.905	<.001	36	view →
UCEC	DFS	Tertile	All	0.221	0.661	<.001	30	view →
STAD	DFS	Tertile	All	0.459	0.726	.010	27	view →
UVM	DFS	Quartile	All	0.813	0.465	.020	19	view →
ESCA	DFS	Tertile	III,IV	0.813	0.268	.017	18	view →
LIHC	OS	Tertile	All	0.164	0.704	.025	9	view →
SKCM	DFS	Quartile	III,IV	0.389	0.195	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

XIRP2-AS1–HNSC (OS)

Open the HNSC breakdown →