XIRP1

Across TCGA pan-cancer cohorts, XIRP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated XIRP1 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher XIRP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated XIRP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUAD, KIRC, and ACC are the cancer types where XIRP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
KIRC	OS	Median	All	0.229	0.630	.040	8	view →
ACC	OS	Median	All	0.268	0.819	.016	8	view →
SKCM	DFS	Median	II,III,IV	0.364	0.188	.007	7	view →
BLCA	OS	Median	IV	0.130	0.599	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

XIRP1–LUAD (DFS)

Open the LUAD breakdown →