XIRP1

Across TCGA pan-cancer cohorts, XIRP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated XIRP1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher XIRP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated XIRP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where XIRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.362	0.815	.012	14	view →
CCRCC	OS	Quartile	All	1.000	0.733	.009	9	view →
LSCC	OS	Median	II,III,IV	0.717	0.925	.008	4	view →
HNSC	OS	Median	III,IV	0.576	0.748	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

XIRP1–LUAD (OS)

Open the LUAD breakdown →