XIRP1

Across TCGA patient cohorts, XIRP1 mutation is significantly associated with the RNA expression of many other genes, with 6,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XIRP1-associated genes across cancer lineages are NSD2, KNL1, and SKA1. Each is linked with XIRP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both XIRP1-to-partner and partner-to-XIRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSD2 grouped by XIRP1-low versus XIRP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP1→partner) and Y-score (partner→XIRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NSD2 →	+0.668	+3.476	.002	.002	3	5
UCEC	KNL1 →	+0.499	+1.478	<.001	<.001	3	5
COAD	SKA1 →	+0.648	+2.820	<.001	<.001	3	5
UCEC	MCM6 →	+0.442	+2.263	.001	<.001	3	5
UCEC	CDC45 →	+0.509	+1.675	<.001	<.001	3	5
LUAD	PPM1G →	+0.504	+3.596	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,101 associations by consensus.

NSD2 by XIRP1 expression — STAD

Explore this box plot interactively →