XIRP1

Across TCGA patient cohorts, XIRP1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XIRP1-associated genes across cancer lineages are C-Raf, p27_pT198, and Src. Each is linked with XIRP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XIRP1-to-partner and partner-to-XIRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by XIRP1-low versus XIRP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP1→partner) and Y-score (partner→XIRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.154	+1.915	.003	.009	3	4
LUSC	p27_pT198 →	+0.188	+2.816	.021	.036	3	3
SKCM	Src →	-0.130	-1.222	.029	.003	3	3
UCEC	Rad50 →	-0.181	-1.321	.007	.005	3	3
LUAD	Cyclin-E2 →	+0.242	+2.186	<.001	.034	2	3
BLCA	MIG-6 →	+0.149	+2.820	.013	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

C-Raf by XIRP1 expression — COAD

Explore this box plot interactively →