XIRP1

Across TCGA cell cohorts, XIRP1 mutation is significantly associated with the RNA expression of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XIRP1-associated genes across cancer lineages are IDI2, FAM187B, and OR2M2. Each is linked with XIRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both XIRP1-to-partner and partner-to-XIRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by XIRP1-low versus XIRP1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP1→partner) and Y-score (partner→XIRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IDI2 →	+0.027	+4.321	<.001	<.001	3	3
BLOOD_Myeloma	FAM187B →	+0.014	+3.754	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	OR2M2 →	+0.202	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	UPP2 →	+0.025	+2.929	<.001	.003	3	2
SKIN	ITIH1 →	+0.018	+2.405	.004	.001	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

IDI2 by XIRP1 expression — BLOOD_Myeloma

Explore this box plot interactively →