X-linked inhibitor of apoptosis pseudogene 2Genealiases: []
Q-omics provides the consensus-scored XIAPP2 profile across patient tissues and cancer cell-line models. XIAPP2 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, XIAPP2 is differentially expressed in 8, with the highest sampling consensus in STAD. Additionally, XIAPP2 RNA expression shows 10,739 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight UCEC, STAD, and CCRCC as cancer lineages where XIAPP2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for XIAPP2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes XIAPP2 survival associations across molecular data types. XIAPP2 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible XIAPP2 RNA expression–survival associations across cancer types. High XIAPP2 expression shows unfavorable associations in UCEC, ACC, UVM, KIRC, UCS and MESO. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UCEC as the clearest survival context for XIAPP2 RNA expression.
This table summarizes XIAPP2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in STAD for RNA.
This table ranks reproducible tumor–normal expression differences for XIAPP2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. XIAPP2 shows lower tumor expression in COAD, THCA and KICH and higher tumor expression in STAD, KIRC and BLCA. The STAD box plot shows higher XIAPP2 RNA expression in tumor versus normal tissue (log2 FC = +0.104, t-test p = .002).
This table shows molecular features associated with XIAPP2 in patient tissues and cancer cell lines. In patient samples, XIAPP2 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set.
