XIAP

Across TCGA pan-cancer cohorts, XIAP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XIAP data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher XIAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated XIAP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where XIAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.277	0.797	<.001	38	view →
LSCC	OS	Quartile	II,III,IV	0.622	1.000	<.001	19	view →
PDAC	OS	Tertile	All	0.296	0.522	.014	8	view →
HNSC	DFS	Median	All	0.329	0.872	.014	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
UCEC	OS	Median	All	0.983	0.871	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XIAP–CCRCC (DFS)

Open the CCRCC breakdown →