XIAP

Across TCGA cell cohorts, XIAP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,186 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XIAP-associated GO terms across cancer lineages are Macroautophagy, Phosphatidylinositol biosynthetic process, and Regulation of post-translational protein modification. Each is linked with XIAP in more than 14 cancer types. Because this analysis shows association rather than direction, both XIAP-to-partner and partner-to-XIAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by XIAP-low versus XIAP-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XIAP→partner) and Y-score (partner→XIAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Macroautophagy →	+0.068	+0.736	.006	.004	3	15
BREAST	Phosphatidylinositol biosynthetic process →	+0.062	+0.891	<.001	<.001	3	15
LUNG_SCLC	Regulation of post-translational protein modification →	+0.047	+0.663	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of organelle assembly →	+0.043	+0.785	.002	.001	3	13
SOFT_TISSUE	Regulation of stress-activated MAPK cascade →	+0.089	+0.770	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Stress granule assembly →	+0.086	+0.637	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,186 associations by consensus.

Macroautophagy by XIAP expression — OESOPHAGUS

Explore this box plot interactively →