XG

Across TCGA pan-cancer cohorts, XG RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated XG data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher XG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated XG expression acts as an unfavorable survival marker, although some lineages such as ESCA and CHOL show a favorable association.

STAD, ACC, and LGG are the cancer types where XG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.486	0.649	<.001	89	view →
ACC	DFS	Median	All	0.419	0.745	<.001	69	view →
LGG	DFS	Median	All	0.647	0.819	<.001	48	view →
BLCA	DFS	Quartile	IV	0.246	0.627	.004	46	view →
BRCA	OS	Quartile	II,III,IV	0.577	0.722	.003	34	view →
ESCA	DFS	Tertile	III,IV	0.548	0.252	<.001	24	view →
CHOL	DFS	Tertile	All	0.859	0.110	.003	20	view →
LIHC	OS	Median	III,IV	0.207	0.636	.002	17	view →
CESC	DFS	Quartile	III,IV	0.195	0.734	.023	16	view →
UVM	DFS	Quartile	III,IV	0.281	0.922	.006	13	view →
THYM	DFS	Quartile	II,III,IV	0.904	0.493	.028	12	view →
UCEC	DFS	Tertile	All	0.925	0.870	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

XG–STAD (OS)

Open the STAD breakdown →