XG

Across TCGA pan-cancer cohorts, XG RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of XG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where XG RNA is repressed in tumor relative to normal tissue. In most cancer types XG is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRP are the cancer types where XG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.040	<.001	9	view →
THCA	Female	II,III,IV	−1.097	<.001	8	view →
KIRP	All	All	−0.565	<.001	8	view →
LUSC	Male	All	+2.000	<.001	7	view →
BRCA	All	III,IV	−1.187	<.001	6	view →
KIRC	Male	II,III,IV	−0.465	.004	6	view →
HNSC	All	All	+0.569	.014	5	view →
LIHC	All	All	−0.433	<.001	5	view →
LUAD	Female	All	−0.467	<.001	4	view →
UCEC	All	All	+0.816	.041	2	view →
PRAD	All	All	−0.675	<.001	2	view →
CHOL	All	All	−0.646	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

XG–KICH

Open the KICH breakdown →