XCL2

Across TCGA cell cohorts, XCL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 847 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible XCL2-associated GO terms across cancer lineages are Chemokine-mediated signaling pathway, Positive regulation of CD8-positive, alpha-beta T cell activation, and Dihydrofolate metabolic process. Each is linked with XCL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both XCL2-to-partner and partner-to-XCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chemokine-mediated signaling pathway grouped by XCL2-low versus XCL2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XCL2→partner) and Y-score (partner→XCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Chemokine-mediated signaling pathway →	-0.096	-0.053	<.001	.004	3	5
LUNG_SCLC	Positive regulation of CD8-positive, alpha-beta T cell activation →	-0.169	-0.113	.004	.007	3	4
BLOOD_Lymphoma	Dihydrofolate metabolic process →	-0.107	-1.058	<.001	.001	3	4
LARGE_INTESTINE	mRNA catabolic process →	+0.036	+0.047	.007	.004	3	4
LARGE_INTESTINE	RNA localization →	+0.054	+0.047	.003	.001	3	4
LARGE_INTESTINE	Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway →	+0.158	+0.057	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 847 associations by consensus.

Chemokine-mediated signaling pathway by XCL2 expression — LARGE_INTESTINE

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