XCL2

Across TCGA pan-cancer cohorts, XCL2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated XCL2 data layer compared with 1 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher XCL2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated XCL2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UCEC are the cancer types where XCL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.457	0.248	<.001	131	view →
HNSC	OS	Quartile	All	0.814	0.669	<.001	102	view →
UCEC	OS	Tertile	III,IV	0.710	0.402	.003	72	view →
BRCA	DFS	Tertile	All	0.569	0.489	.002	39	view →
ACC	DFS	Quartile	All	0.917	0.332	.001	28	view →
THCA	DFS	Tertile	IV	1.000	0.524	.004	27	view →
LIHC	DFS	Median	II,III,IV	0.505	0.340	.003	24	view →
UVM	OS	Median	All	0.446	0.772	.011	23	view →
THYM	OS	Median	All	0.648	0.971	.003	23	view →
LGG	OS	Median	All	0.851	0.928	<.001	22	view →
DLBC	DFS	Tertile	III,IV	0.077	1.000	.017	22	view →
KIRC	OS	Quartile	All	0.539	0.716	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

XCL2–SKCM (OS)

Open the SKCM breakdown →