XCL1

Across TCGA cell cohorts, XCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,225 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible XCL1-associated GO terms across cancer lineages are Positive regulation of CD8-positive, alpha-beta T cell proliferation, Positive regulation of CD8-positive, alpha-beta T cell activation, and Negative regulation of T cell mediated immunity. Each is linked with XCL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both XCL1-to-partner and partner-to-XCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of CD8-positive, alpha-beta T cell proliferation grouped by XCL1-low versus XCL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XCL1→partner) and Y-score (partner→XCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of CD8-positive, alpha-beta T cell proliferation →	-0.267	-1.196	<.001	<.001	3	14
LUNG_SCLC	Positive regulation of CD8-positive, alpha-beta T cell activation →	-0.256	-1.608	<.001	<.001	3	9
BLOOD_Myeloma	Negative regulation of T cell mediated immunity →	-0.148	-1.006	.008	.009	3	8
STOMACH	RNA export from nucleus →	+0.136	+1.101	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of CD8-positive, alpha-beta T cell activation →	-0.186	-1.260	<.001	<.001	3	7
OESOPHAGUS	RNA catabolic process →	+0.071	+1.398	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,225 associations by consensus.

Positive regulation of CD8-positive, alpha-beta T cell proliferation by XCL1 expression — LUNG_SCLC

Explore this box plot interactively →