XAGE3

Across TCGA patient cohorts, XAGE3 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible XAGE3-associated genes across cancer lineages are OR2P1P, RNU6-629P, and PINCR. Each is linked with XAGE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both XAGE3-to-partner and partner-to-XAGE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2P1P grouped by XAGE3-low versus XAGE3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE3→partner) and Y-score (partner→XAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR2P1P →	+0.141	+5.554	.006	.004	3	2
UCEC	RNU6-629P →	+0.352	+4.722	<.001	.004	3	1
UCEC	PINCR →	+0.668	+3.600	<.001	.009	3	1
UCEC	RPS27AP17 →	+0.433	+3.766	.006	.006	3	1
UCEC	SNRPGP7 →	+0.283	+4.335	<.001	.007	3	1
UCEC	RPS15AP18 →	+0.387	+4.061	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

OR2P1P by XAGE3 expression — LUAD

Explore this box plot interactively →