XAGE2

Across TCGA patient cohorts, XAGE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,763 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible XAGE2-associated GO terms across cancer lineages are Positive regulation of establishment of protein localization to telomere, Regulation of proteolysis involved in protein catabolic process, and Protein insertion into membrane. Each is linked with XAGE2 in more than 10 cancer types. Because this analysis shows association rather than direction, both XAGE2-to-partner and partner-to-XAGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of establishment of protein localization to telomere grouped by XAGE2-low versus XAGE2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE2→partner) and Y-score (partner→XAGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of establishment of protein localization to telomere →	+0.063	+0.248	<.001	.003	3	11
DLBC	Regulation of proteolysis involved in protein catabolic process →	+0.076	+0.112	<.001	.008	3	10
STAD	Protein insertion into membrane →	+0.067	+0.408	<.001	<.001	3	10
STAD	Protein folding →	+0.065	+0.303	<.001	.002	2	11
STAD	Regulation of establishment of protein localization to chromosome →	+0.058	+0.343	<.001	<.001	3	10
STAD	Mitochondrial translation →	+0.090	+0.534	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,763 associations by consensus.

Positive regulation of establishment of protein localization to telomere by XAGE2 expression — ESCA

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