XAGE2

Across TCGA pan-cancer cohorts, XAGE2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of XAGE2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where XAGE2 RNA is repressed in tumor relative to normal tissue. In most cancer types XAGE2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where XAGE2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XAGE2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.662	<.001	12	view →
KICH	Female	All	−1.213	<.001	10	view →
LUAD	Male	II,III,IV	−3.083	<.001	9	view →
LUSC	All	II,III,IV	−2.560	<.001	6	view →
KIRP	Female	All	−0.379	.003	4	view →
BRCA	All	III,IV	−0.218	<.001	4	view →
THCA	All	II,III,IV	−0.033	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

XAGE2–KIRC

Open the KIRC breakdown →