XAGE2

Across TCGA patient cohorts, XAGE2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XAGE2-associated genes across cancer lineages are Adipocytes, CD8+ Tem, and Plasma cells. Each is linked with XAGE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both XAGE2-to-partner and partner-to-XAGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adipocytes grouped by XAGE2-low versus XAGE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE2→partner) and Y-score (partner→XAGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Adipocytes →	+0.029	+2.336	.002	.035	3	3
UCEC	CD8+ Tem →	+0.004	+4.896	<.001	.036	3	1
UCEC	Plasma cells →	-0.024	-3.127	.046	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Adipocytes by XAGE2 expression — UCEC

Explore this box plot interactively →