XAGE2

Across TCGA cell cohorts, XAGE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 537 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible XAGE2-associated GO terms across cancer lineages are Nuclear histone mRNA catabolic process, Cellular response to folic acid, and Hippo signaling. Each is linked with XAGE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both XAGE2-to-partner and partner-to-XAGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear histone mRNA catabolic process grouped by XAGE2-low versus XAGE2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE2→partner) and Y-score (partner→XAGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Nuclear histone mRNA catabolic process →	+0.070	+0.612	<.001	.003	3	5
LIVER	Cellular response to folic acid →	+1.549	+1.666	<.001	.006	3	4
BREAST	Hippo signaling →	+0.065	+1.033	.003	.005	2	5
SKIN	Protein localization to vacuole →	+0.043	+0.860	.001	.004	3	4
LIVER	Glycogen catabolic process →	+0.080	+0.957	.001	.007	3	4
OVARY	Endocardial cushion development →	-0.055	-1.411	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 537 associations by consensus.

Nuclear histone mRNA catabolic process by XAGE2 expression — CNS

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