XACT

Across TCGA patient cohorts, XACT RNA expression is significantly associated with the protein abundance of many other proteins, with 7,994 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XACT-associated proteins across cancer lineages are EPB41L2, PLXDC2, and PLXDC2_S506. Each is linked with XACT in more than 2 cancer types. Because this analysis shows association rather than direction, both XACT-to-partner and partner-to-XACT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XACT versus EPB41L2 in GBM, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XACT→partner) and Y-score (partner→XACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EPB41L2 →	+0.401	+0.258	<.001	<.001	3	3
GBM	PLXDC2 →	+0.437	+0.312	<.001	<.001	3	2
GBM	PLXDC2_S506 →	+0.669	+0.252	<.001	.001	2	3
CCRCC	PRAM1 →	+0.471	+0.028	.001	.002	3	2
OV	FAM171A1 →	+1.084	+0.002	<.001	.003	3	2
HNSC	SHANK2_S67 →	-1.229	-0.957	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,994 associations by consensus.

XACT vs EPB41L2 — GBM

Explore this scatter interactively →