XACT

Across TCGA pan-cancer cohorts, XACT RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated XACT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher XACT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated XACT expression acts as an unfavorable survival marker, although some lineages such as READ and ESCA show a favorable association.

KIRC, MESO, and COAD are the cancer types where XACT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.391	0.706	.001	144	view →
MESO	OS	Tertile	II,III,IV	0.121	0.571	.004	54	view →
COAD	DFS	Quartile	IV	0.279	0.561	.002	39	view →
KIRP	DFS	Tertile	II,III,IV	0.115	0.779	<.001	36	view →
LUAD	OS	Tertile	II,III,IV	0.367	0.752	.015	36	view →
READ	DFS	Tertile	All	0.796	0.421	.011	25	view →
BLCA	DFS	Tertile	IV	0.137	0.483	.002	18	view →
PRAD	DFS	Tertile	All	0.885	0.947	.004	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
LAML	DFS	Median	All	0.468	0.647	.011	10	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
ESCA	OS	Tertile	III,IV	0.677	0.366	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

XACT–KIRC (OS)

Open the KIRC breakdown →