XAB2

Across TCGA patient cohorts, XAB2 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XAB2-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and INPP4B. Each is linked with XAB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both XAB2-to-partner and partner-to-XAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by XAB2-low versus XAB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAB2→partner) and Y-score (partner→XAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.310	+2.837	<.001	.001	3	3
COAD	EGFR_pY1068 →	-0.461	-3.000	.002	.034	3	2
COAD	INPP4B →	-0.540	-3.313	.002	.010	3	2
COAD	TAZ →	+0.185	+2.195	.045	.034	3	2
UCEC	eIF4G →	+0.293	+2.459	.006	.018	3	2
UCEC	HSP70 →	-0.286	-2.575	.040	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

4E-BP1 by XAB2 expression — UCEC

Explore this box plot interactively →