XAB2

Across TCGA cell cohorts, XAB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XAB2-associated GO terms across cancer lineages are Spliceosomal conformational changes to generate catalytic conformation, Positive regulation of anaphase-promoting complex-dependent catabolic process, and Regulation of protein localization to chromatin. Each is linked with XAB2 in more than 18 cancer types. Because this analysis shows association rather than direction, both XAB2-to-partner and partner-to-XAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal conformational changes to generate catalytic conformation grouped by XAB2-low versus XAB2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAB2→partner) and Y-score (partner→XAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Spliceosomal conformational changes to generate catalytic conformation →	+0.097	+0.754	<.001	.003	3	19
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.163	+0.598	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.138	+0.925	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.185	+1.049	<.001	<.001	3	17
LARGE_INTESTINE	mRNA cis splicing, via spliceosome →	+0.097	+0.668	<.001	<.001	3	17
PANCREAS	Spliceosomal tri-snRNP complex assembly →	+0.102	+0.755	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,519 associations by consensus.

Spliceosomal conformational changes to generate catalytic conformation by XAB2 expression — LUNG_NSCLC_LUSC

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