XAB2

Across TCGA cell cohorts, XAB2 mutation is significantly associated with the mutation status of many other genes, with 4,890 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XAB2-associated genes across cancer lineages are TRPC3, CSF3R, and NUP214. Each is linked with XAB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both XAB2-to-partner and partner-to-XAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPC3 grouped by XAB2-low versus XAB2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAB2→partner) and Y-score (partner→XAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TRPC3 →	+4.807	+4.807	.008	.008	1	5
BLOOD_Leukemia	CSF3R →	+2.913	+2.913	.003	.003	1	5
UPPER_AERODIGESTIVE_TRACT	NUP214 →	+3.660	+3.193	.006	.006	1	5
BREAST	MAP4 →	+4.857	+4.297	.009	.009	1	4
LARGE_INTESTINE	HEXD →	+5.182	+3.485	<.001	<.001	1	4
BLOOD_Lymphoma	KCNQ3 →	+4.014	+4.969	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,890 associations by consensus.

TRPC3 by XAB2 expression — STOMACH

Explore this box plot interactively →