WWTR1

Across TCGA cell cohorts, WWTR1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWTR1-associated genes across cancer lineages are CCDC179, RBMY1A1, and TFDP3. Each is linked with WWTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWTR1-to-partner and partner-to-WWTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC179 grouped by WWTR1-low versus WWTR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWTR1→partner) and Y-score (partner→WWTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC179 →	+0.114	+3.944	<.001	.006	3	2
LUNG_SCLC	RBMY1A1 →	+1.372	+4.044	<.001	.009	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+4.196	.002	.002	3	1
LARGE_INTESTINE	ADH1A →	+0.110	+3.920	.007	.005	3	1
LARGE_INTESTINE	OR2J3 →	+0.044	+3.920	<.001	.005	3	1
BREAST	OR10J5 →	+0.078	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CCDC179 by WWTR1 expression — BLOOD_Leukemia

Explore this box plot interactively →