WWTR1-IT1

Across TCGA pan-cancer cohorts, WWTR1-IT1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated WWTR1-IT1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WWTR1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WWTR1-IT1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and HNSC show a favorable association.

UCEC, KIRC, and UVM are the cancer types where WWTR1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.787	0.911	.001	80	view →
KIRC	DFS	Median	II,III,IV	0.439	0.605	.002	66	view →
UVM	DFS	Tertile	All	0.604	0.806	.011	30	view →
LGG	DFS	Quartile	All	0.726	0.855	<.001	25	view →
ACC	DFS	Median	All	0.235	0.713	.009	24	view →
LIHC	DFS	Quartile	II,III,IV	0.582	0.228	.010	23	view →
HNSC	DFS	Median	IV	0.711	0.570	.011	22	view →
LUSC	OS	Tertile	All	0.520	0.361	<.001	21	view →
LAML	DFS	Tertile	All	0.400	0.693	.007	18	view →
GBM	DFS	Median	All	0.191	0.318	.001	18	view →
READ	DFS	Tertile	IV	0.402	0.656	.017	12	view →
KIRP	DFS	Tertile	All	0.964	0.741	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

WWTR1-IT1–UCEC (OS)

Open the UCEC breakdown →