WWTR1-IT1

Across TCGA pan-cancer cohorts, WWTR1-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WWTR1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WWTR1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types WWTR1-IT1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and CHOL are the cancer types where WWTR1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WWTR1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.454	<.001	10	view →
BRCA	All	III,IV	−0.410	<.001	6	view →
CHOL	All	All	+0.586	<.001	5	view →
KIRC	Male	IV	+0.185	.019	5	view →
KICH	All	All	−0.324	<.001	4	view →
BLCA	Female	IV	−0.493	.003	3	view →
LUSC	All	All	−0.209	.005	2	view →
LUAD	Female	II,III,IV	−0.338	.035	1	view →
KIRP	All	All	−0.239	.009	1	view →
LIHC	Male	All	+0.071	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

WWTR1-IT1–THCA

Open the THCA breakdown →