WWTR1-AS1

Across TCGA pan-cancer cohorts, WWTR1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of WWTR1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WWTR1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types WWTR1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and BRCA are the cancer types where WWTR1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WWTR1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.457	<.001	11	view →
KIRC	Male	II,III,IV	−0.516	<.001	7	view →
BRCA	Female	All	−0.138	<.001	6	view →
LIHC	Female	All	+0.120	<.001	6	view →
CHOL	Female	All	+0.490	<.001	5	view →
LUAD	Female	All	−0.112	.010	4	view →
READ	Female	All	−0.210	.025	2	view →
UCEC	All	All	−0.206	.023	2	view →
LUSC	All	All	+0.178	.006	2	view →
PRAD	All	All	−0.113	.038	2	view →
HNSC	Male	IV	+0.241	.049	1	view →
BLCA	All	IV	−0.224	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

WWTR1-AS1–THCA

Open the THCA breakdown →