Across TCGA pan-cancer cohorts, WWOX mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WWOX data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WWOX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WWOX expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where WWOX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.971	0.682	.004	14	view →
LSCC	OS	Quartile	All	0.926	0.650	.007	13	view →
UCEC	OS	Quartile	III,IV	0.287	1.000	.040	6	view →
GBM	OS	Quartile	All	0.679	0.879	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: WWOX tumor-vs-normal RNA expression · all WWOX data types