WWOX

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WWOX mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWOX-associated genes across cancer lineages are TRAJ47, TRAJ42, and TMEM269. Each is linked with WWOX in more than 1 cancer types. Because this analysis shows association rather than direction, both WWOX-to-partner and partner-to-WWOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWOX→partner) and Y-score (partner→WWOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCTRAJ47 →+0.434+3.684.001.00532
CESCTRAJ42 →+0.436+3.608.006.00432
UCECTMEM269 →+0.125+1.906.007.00132
HNSCMIR6790 →+0.581+7.623<.001<.00132
BLCANPVF →+0.030+5.444.004.00232
UCECDPEP1 →-1.074-2.896.002.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

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