WWOX

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WWOX mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWOX-associated genes across cancer lineages are Bid, EGFR_pY1068, and p62 Lck ligand. Each is linked with WWOX in more than 1 cancer types. Because this analysis shows association rather than direction, both WWOX-to-partner and partner-to-WWOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWOX→partner) and Y-score (partner→WWOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADBid →+0.128+3.025.029.01932
UCECEGFR_pY1068 →-0.280-3.459.002.00532
UCECp62 Lck ligand →+0.441+2.700<.001.00532
UCECPDCD4 →-0.446-1.502.009.03032
UCECS6_pS240_S244 →+0.370+1.502.013.03032
UCECSmad3 →+0.164+2.000.002.03032
Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration