Across TCGA cell cohorts, WWOX mutation is significantly associated with the RNA expression of many other genes, with 302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWOX-associated genes across cancer lineages are OR1L6, NAT8B, and FHL5. Each is linked with WWOX in more than 1 cancer types. Because this analysis shows association rather than direction, both WWOX-to-partner and partner-to-WWOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWOX→partner) and Y-score (partner→WWOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	2
LUNG_NSCLC_LUAD	NAT8B →	+0.050	+4.371	<.001	.005	3	2
LUNG_NSCLC_LUSC	FHL5 →	+0.023	+4.643	<.001	.008	3	1
LUNG_SCLC	KRT25 →	+0.028	+4.058	<.001	.007	3	1
LARGE_INTESTINE	EIF3L →	+0.566	+3.237	.001	.003	3	1
LARGE_INTESTINE	RPL3 →	+0.482	+3.237	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 302 associations by consensus.

Exploration

WWOX survival (RNA) · tumor vs normal (RNA) · all WWOX data types