WWC2

Across TCGA patient cohorts, WWC2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,511 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WWC2-associated genes across cancer lineages are WWC2-AS2, RAVER2, and SPARCL1. Each is linked with WWC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both WWC2-to-partner and partner-to-WWC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WWC2 versus WWC2-AS2 in CCRCC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC2→partner) and Y-score (partner→WWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	WWC2-AS2 →	+0.683	+0.281	<.001	<.001	3	5
PDAC	RAVER2 →	-0.756	-0.507	.001	<.001	3	4
CCRCC	SPARCL1 →	+1.011	+0.248	.005	.004	3	4
CCRCC	TLL1 →	+1.357	+0.355	<.001	<.001	3	4
CCRCC	CA4 →	+1.430	+0.321	<.001	.001	3	4
BRCA	CXCL12 →	+1.027	+0.372	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,511 associations by consensus.

WWC2 vs WWC2-AS2 — CCRCC

Explore this scatter interactively →