WWC2

Across TCGA patient cohorts, WWC2 mutation is significantly associated with the RNA expression of many other genes, with 6,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWC2-associated genes across cancer lineages are ARPP19P2, MIRLET7BHG, and PBK. Each is linked with WWC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WWC2-to-partner and partner-to-WWC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARPP19P2 grouped by WWC2-low versus WWC2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC2→partner) and Y-score (partner→WWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARPP19P2 →	+0.212	+4.425	<.001	.006	3	3
COAD	MIRLET7BHG →	+0.618	+3.611	<.001	.001	3	3
UCEC	PBK →	+0.954	+2.595	<.001	<.001	3	3
COAD	B3GNT4 →	+0.410	+3.584	.005	.002	3	3
UCEC	MUC20 →	-0.967	-2.059	<.001	.001	3	3
UCEC	TIMM22 →	+0.489	+3.545	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,600 associations by consensus.

ARPP19P2 by WWC2 expression — HNSC

Explore this box plot interactively →