WWC2

Across TCGA patient cohorts, WWC2 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWC2-associated genes across cancer lineages are FASN, Cyclin-B1, and 4E-BP1_pT70. Each is linked with WWC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WWC2-to-partner and partner-to-WWC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by WWC2-low versus WWC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC2→partner) and Y-score (partner→WWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.324	+2.137	.003	<.001	3	3
UCEC	Cyclin-B1 →	+0.748	+1.830	<.001	<.001	3	3
COAD	4E-BP1_pT70 →	+0.119	+2.467	.022	.011	3	3
UCEC	eIF4E →	+0.182	+1.830	.002	<.001	3	2
UCEC	FoxM1 →	+0.188	+1.632	.009	<.001	3	2
UCEC	Notch1 →	+0.117	+1.257	.003	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

FASN by WWC2 expression — UCEC

Explore this box plot interactively →