WWC2

Across TCGA cell cohorts, WWC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,205 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWC2-associated GO terms across cancer lineages are Regulation of hippo signaling, Hippo signaling, and Negative regulation of hippo signaling. Each is linked with WWC2 in more than 14 cancer types. Because this analysis shows association rather than direction, both WWC2-to-partner and partner-to-WWC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by WWC2-low versus WWC2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC2→partner) and Y-score (partner→WWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of hippo signaling →	+0.120	+1.353	<.001	<.001	3	15
STOMACH	Hippo signaling →	+0.136	+2.448	<.001	<.001	3	14
BONE	Negative regulation of hippo signaling →	+0.147	+2.034	<.001	<.001	3	13
STOMACH	Regulation of modification of postsynaptic structure →	+0.173	+2.422	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of modification of synaptic structure →	+0.152	+1.950	<.001	.002	2	13
BONE	Schwann cell differentiation →	+0.169	+2.068	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,205 associations by consensus.

Regulation of hippo signaling by WWC2 expression — OESOPHAGUS

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