WWC2-AS2

Across TCGA pan-cancer cohorts, WWC2-AS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WWC2-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WWC2-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types WWC2-AS2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where WWC2-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WWC2-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.519	<.001	11	view →
THCA	Male	III,IV	−1.305	<.001	11	view →
LUAD	Female	III,IV	−1.012	<.001	8	view →
UCEC	All	III,IV	−0.935	<.001	6	view →
LUSC	Female	All	−0.782	<.001	6	view →
KIRP	Male	All	−0.567	<.001	6	view →
BRCA	All	II,III,IV	−0.527	<.001	6	view →
HNSC	All	All	+0.195	.003	6	view →
KIRC	All	All	+0.319	.002	4	view →
PRAD	All	All	−0.459	<.001	2	view →
LIHC	All	All	+0.165	.004	2	view →
READ	Female	All	−0.422	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WWC2-AS2–KICH

Open the KICH breakdown →