WWC1

Across TCGA pan-cancer cohorts, WWC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WWC1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WWC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WWC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where WWC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.933	0.412	<.001	45	view →
LSCC	DFS	Median	III,IV	0.868	0.359	.006	16	view →
PDAC	DFS	Median	III,IV	0.891	0.317	.009	13	view →
CCRCC	OS	Tertile	II,III,IV	0.985	0.133	.027	7	view →
GBM	OS	Quartile	All	0.198	0.608	.016	6	view →
LUAD	OS	Median	All	0.883	0.788	.036	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WWC1–HNSC (OS)

Open the HNSC breakdown →