WWC1

Across TCGA pan-cancer cohorts, WWC1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WWC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WWC1 RNA is repressed in tumor relative to normal tissue. In most cancer types WWC1 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where WWC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WWC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.932	<.001	11	view →
COAD	Male	II,III,IV	+1.010	<.001	10	view →
BLCA	Male	III,IV	+2.767	<.001	8	view →
LUAD	Male	II,III,IV	−0.932	<.001	8	view →
KICH	Male	All	−1.969	<.001	7	view →
LUSC	Female	II,III,IV	−1.771	<.001	6	view →
LIHC	All	All	+0.651	<.001	6	view →
HNSC	Female	All	−0.548	.014	5	view →
UCEC	All	All	+1.681	.001	4	view →
STAD	All	All	+1.001	.003	4	view →
CHOL	All	All	+2.623	<.001	3	view →
PRAD	All	All	+0.831	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WWC1–KIRC

Open the KIRC breakdown →