WWC1

Across TCGA patient cohorts, WWC1 mutation is significantly associated with the RNA expression of many other genes, with 2,751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWC1-associated genes across cancer lineages are LINC02319, RNU6-213P, and KRTAP4-11. Each is linked with WWC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WWC1-to-partner and partner-to-WWC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02319 grouped by WWC1-low versus WWC1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC1→partner) and Y-score (partner→WWC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LINC02319 →	+0.217	+3.827	<.001	.006	3	3
READ	RNU6-213P →	+0.794	+4.400	<.001	.002	3	2
KIRP	KRTAP4-11 →	+0.058	+5.159	<.001	.007	3	2
READ	IQCF3 →	+0.075	+3.724	<.001	.007	3	2
READ	LINC01343 →	+0.021	+4.315	<.001	.002	3	2
READ	LINC02690 →	+0.255	+3.724	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,751 associations by consensus.

LINC02319 by WWC1 expression — READ

Explore this box plot interactively →