WWC1

Across TCGA patient cohorts, WWC1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWC1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and FoxM1. Each is linked with WWC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both WWC1-to-partner and partner-to-WWC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WWC1-low versus WWC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC1→partner) and Y-score (partner→WWC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.800	+2.415	<.001	.002	3	4
UCEC	eIF4E →	+0.139	+2.222	.042	.010	3	1
UCEC	FoxM1 →	+0.178	+2.125	.034	.010	3	1
UCEC	JNK2 →	+0.128	+1.222	.047	.035	3	1
UCEC	MEK1 →	+0.415	+2.321	<.001	<.001	3	1
UCEC	Notch1 →	+0.168	+1.512	<.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by WWC1 expression — UCEC

Explore this box plot interactively →