WWC1

Across TCGA cell cohorts, WWC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,866 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWC1-associated GO terms across cancer lineages are Positive regulation of blood-brain barrier permeability, Establishment of protein localization to membrane, and Epithelial cell development. Each is linked with WWC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both WWC1-to-partner and partner-to-WWC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of blood-brain barrier permeability grouped by WWC1-low versus WWC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC1→partner) and Y-score (partner→WWC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of blood-brain barrier permeability →	+0.973	+2.036	.003	<.001	3	10
STOMACH	Establishment of protein localization to membrane →	+0.074	+1.950	.003	.005	3	9
OVARY	Epithelial cell development →	+0.076	+1.472	<.001	<.001	3	8
LARGE_INTESTINE	Regulation of hematopoietic stem cell proliferation →	+0.139	+1.254	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of macrophage fusion →	+0.226	+1.023	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of macrophage fusion →	+0.226	+1.023	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

Positive regulation of blood-brain barrier permeability by WWC1 expression — BONE

Explore this box plot interactively →