WWC1

Across TCGA cell cohorts, WWC1 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWC1-associated genes across cancer lineages are ADGRE3, GAGE12J, and C20orf85. Each is linked with WWC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWC1-to-partner and partner-to-WWC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE3 grouped by WWC1-low versus WWC1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC1→partner) and Y-score (partner→WWC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	1
KIDNEY	GAGE12J →	+0.293	+5.000	<.001	.005	3	1
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4D6 →	+0.035	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR51L1 →	+0.027	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ADGRE3 by WWC1 expression — KIDNEY

Explore this box plot interactively →