WTIP

Across TCGA patient cohorts, WTIP mutation is significantly associated with the RNA expression of many other genes, with 1,703 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WTIP-associated genes across cancer lineages are RNA5SP146, RPL35AP30, and LINC02503. Each is linked with WTIP in more than 1 cancer types. Because this analysis shows association rather than direction, both WTIP-to-partner and partner-to-WTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP146 grouped by WTIP-low versus WTIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WTIP→partner) and Y-score (partner→WTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP146 →	+0.440	+2.872	<.001	<.001	3	2
BRCA	RPL35AP30 →	+0.144	+5.122	.001	.008	3	2
SKCM	LINC02503 →	+0.031	+4.282	<.001	.009	3	2
UCEC	LINC01899 →	+0.078	+2.134	.003	.006	3	2
UCEC	RNA5SP325 →	+0.820	+1.974	<.001	.005	3	2
SKCM	RNA5SP24 →	+0.365	+4.884	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,703 associations by consensus.

RNA5SP146 by WTIP expression — UCEC

Explore this box plot interactively →