WTIP

Across TCGA pan-cancer cohorts, WTIP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WTIP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WTIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WTIP is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where WTIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WTIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.514	<.001	10	view →
KICH	Female	All	−1.774	<.001	9	view →
BLCA	Male	III,IV	−0.871	.001	8	view →
LUAD	Female	All	−0.829	<.001	7	view →
KIRC	All	II,III,IV	−0.417	<.001	7	view →
UCEC	All	All	−1.286	<.001	6	view →
BRCA	All	III,IV	−0.986	<.001	6	view →
LUSC	All	All	−0.871	<.001	6	view →
CHOL	Male	All	+1.950	<.001	5	view →
LIHC	Female	All	+0.638	.006	4	view →
KIRP	All	All	−0.539	.002	2	view →
PRAD	All	All	−0.228	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WTIP–THCA

Open the THCA breakdown →