WTIP

Across TCGA patient cohorts, WTIP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WTIP-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and Notch1. Each is linked with WTIP in more than 1 cancer types. Because this analysis shows association rather than direction, both WTIP-to-partner and partner-to-WTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by WTIP-low versus WTIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WTIP→partner) and Y-score (partner→WTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.159	-2.459	.008	.020	3	1
UCEC	Ku80 →	+0.262	+3.009	.022	.019	3	1
UCEC	Notch1 →	+0.171	+2.459	.012	.020	3	1
UCEC	Rab25 →	-0.446	-3.321	.005	.010	3	1
UCEC	Rad50 →	-0.345	-3.308	.003	.009	3	1
UCEC	Annexin_VII →	-0.170	-2.459	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a_pS318_S321 by WTIP expression — UCEC

Explore this box plot interactively →