WTIP

Across TCGA cell cohorts, WTIP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WTIP-associated genes across cancer lineages are MYOD1, AVP, and CDX4. Each is linked with WTIP in more than 1 cancer types. Because this analysis shows association rather than direction, both WTIP-to-partner and partner-to-WTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by WTIP-low versus WTIP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WTIP→partner) and Y-score (partner→WTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.041	+3.217	<.001	.006	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	OR5C1 →	+0.031	+3.115	.003	.004	3	1
LARGE_INTESTINE	IBSP →	+0.156	+2.994	.007	.006	3	1
BREAST	NPAP1 →	+0.013	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MYOD1 by WTIP expression — BLOOD_Leukemia

Explore this box plot interactively →